منابع مشابه
Engineering Signal Transduction Pathways
Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...
متن کاملSignal Transduction Pathways for Leptin
Leptin is a critical regulator of energy balance in mammals and has served as a launch point for innumerable studies examining the regulation of food intake and energy expenditure (1). At high physiological concentrations, leptin causes a decrease in food intake, an increase in energy expenditure, and a shift to increased fatty acid oxidation. These physiological shifts lead to a decrease in bo...
متن کاملSimulation of signal transduction pathways
Signal transduction is about how molecular mechanisms in cells are used to receive, process and respond to signals from outside and inside of the cell. The term signal is defined in a dual way in this context: being the molecular state of a molecule, e.g. a protein, and at the same time an abstract logical state (active/inactive). This thesis focuses on intracellular signalling: i.e. receiving ...
متن کاملModelling of Signal Transduction Pathways
This review focusses on modelling of signal transduction pathways. It will introduce the general concepts of modelling and signal transduction, and then proceed with presenting the two most common approaches: Ordinary Di erential Equations (ODE) and Petri Nets (PN). Including an overview about some of the PN upgrades, such as Timed or Coloured Petri Nets, this review will show the major di eren...
متن کاملNeurotrophic Factors and Intracellular Signal Transduction Pathways
A clear limitation of treating diseases of the central nervous system arises from the loss of regenerative potential of the brain at a very early age. Improper development of neural circuits or injury of neurons appears to be permanently fixed in the adult, with seemingly little hope of restorative therapy. This is most clearly true of the spectrum of neurologic diseases, such as neurodegenerat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2005
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.4.3.1556